Nanoparticles - Indian Traditional Medicine - Western Modern Medicine-Physicochemical and Biological Study
Dr. Tridib Bhawmick
Nanoparticles and their interaction with biological systems have been a research focus of many groups nowadays. Physiochemical properties of the materials are manipulated at the nano scale level to create an array of potential new commercial products. It is expected that the number and variety of engineered nanoparticles will increase rapidly over the next few years, and there is a need for new methods to test the potential toxicity of these materials. In this talk I will present my work on the understanding of the risk factor associated with the surface functionalized silica nanoparticles.
Knowledge about factors influencing cellular uptake, like size, surface properties, cell type and endocytotic pathways, enables selection of cells and nanoparticles for applications in vitro and in vivo. For in vivo applications, my work centers on how nanoparticles can cross the blood-brain barrier. In our study we have shown that intercellular adhesion molecule 1 (ICAM-1)-targeted nanocarriers markedly enhanced delivery of therapeutic enzymes, over non-targeted enzymes in mouse brain. In this talk I will also present the results on physicochemical analysis of a particulate Indian traditional medicine (Bhasma) and effects of Bhasma on biological system (in vitro).